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Viagra: Working Mechanism

Introduction


Viagra is used to relaxes the muscles and increase the blood flow in some specific part of our body. Viagra is the well know treatment for erectile dysfunction. This ED pill has been used by millions of men. It has been established itself as the leading brand for the effective treatment of impotence. Viagra restorespotency in men who are not able to gain or maintain an erection on the needed level. It is one of the most commonly sold drugs and people love the results. Viagra is a brand medicine for men who suffer from erectile. The pill is blue and diamond-shaped. The treatment is available in a different dosage.  One pill can change your l boring life to exciting. Sildenafil is a generic version of Viagra.


Ingredients in Viagra

  • The preparation steps for sildenafil are:
  • Carboxamide formation with refluxing thionyl chloride/NH4OH
  • Methylation of 3-propylpyrazole-5-carboxylic acid ethyl ester with hot dimethly sulfate.
  • Hydrolysis with aqueous sodium hydroxide (NaOH) to free acid.
  • Nitration with fuming nitric acid.
  • Cyclization
  • Reduction of a nitro group to amino group.
  • Acylation with 2-ethoxybenzoyl chloride. 



Working on mechanism


Before understanding that how Viagra works or what is the mechanism behind the working of Viagra it is very important to understand the erectile function in men. Sildenafil enhances the effect of NO by inhibiting Phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. The sexual stimulation releases nitric oxide in the corpus cavernosum. The release of nitric oxide activates the enzyme guanylate cyclase which results in the increased levels of cyclic guanosine monophosphate responsible for the penile erections.

In simple words, we can say that Viagra increases the blood flow to the penile nerve which results in an erection.  It allows to maintain an erection during the sexual activity.


Warnings and Precautions of Viagra



  • Patients suffering from any of the following medical conditions must inform doctor prior taking Viagra
  • Diabetes patient should avoid Viagra as it can increase the glucose in the blood, which may results to high blood sugar
  • Kidney or liver problem should take Viagra after consulting with the doctor
  • Any bleeding or disorder like hemophilia
  • Disease of blood called sickle cell anemia
  • Stomach ulcer, viagra may cause bleeding inside the stomach
  •  Color vision problems, it may lead to loss of vision or blurred vision
  • Sudden decrease or loss of hearing.

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